Publikationen

2017

Bachmayr-Heyda, A., Aust, S., Auer, K., Meier, S. M., Schmetterer, K. G., Dekan, S., Gerner, C. & Pils, D. Integrative Systemic and Local Metabolomics with Impact on Survival in High-Grade Serous Ovarian Cancer. Clinical Cancer Research. 23, 8, S. 2081-2092 12 S.


Sommerfeld, N. S., Hejl, M., Klose, M. H. M., Schreiber-Brynzak, E., Bileck, A., Meier, S. M., Gerner, C., Jakupec, M. A., Galanski, M. & Keppler, B. K. Low-Generation Polyamidoamine Dendrimers as Drug Carriers for Platinum(IV) Complexes. European Journal of Inorganic Chemistry. 12, S. 1713-1720 8 S.


Samuel M. Meier, Dominique Kreutz, Lilli Winter, Matthias H.M. Klose, Klaudia Cseh, Tamara Weiss, Andrea Bileck, Beatrix Alte, Johanna C. Mader, Samir Jana, Annesha Chatterjee, Arindam Bhattacharyya, Michaela Hejl, Michael A. Jakupec, Petra Heffeter, Walter Berger, Christian G. Hartinger, Bernhard K. Keppler, Gerhard Wiche and Christopher Gerner. An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin. Angew Chem Int Ed Engl. 2017 [Epub ahead of print]


Aust S, Felix S, Auer K, Bachmayr-Heyda A, Kenner L, Dekan S, Meier SM, Gerner C, Grimm C, Pils D. Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer. Sci Rep. 2017 Mar 7;7:42929.


Hochkogler CM, Lieder B, Rust P, Berry D, Meier SM, Pignitter M, Riva A, Leitinger A, Bruk, A Wagner S, Hans J, Widder S, Ley JP, Krammer GE, Somoza V. A 12-week intervention with nonivamide, a TRPV1 agonist, prevents a dietary-induced body fat gain and increases peripheral serotonin in moderately overweight subjects. Mol Nutr Food Res. 2016 Dec 24.


Tahir A, Bileck A, Muqaku B, Niederstaetter L,Kreutz D, Mayer RL, Wolrab D, Meier SM, Slany A, Gerner C. Combined proteome and eicosanoid profiling reveals novel implications of human fibroblasts in chronic inflammation. Anal Chem. 2017 [Epub ahead of print]

2016

Muqaku B, Eisinger M, Meier SM, Tahir A, Prokop T, Haferkamp S, Slany A, Reichle A, Gerner C. Multi-omics analysis of serum samples demonstrates reprogramming of organ functions via systemic calcium mobilization and platelet activation in metastatic melanoma. Mol Cell Proteomics. 2016 Nov 22. pii: mcp.M116.063313. [Epub ahead of print]


Kreutz D, Bileck A, Plessl K, Wolrab D, Groessl M, Keppler BK, Meier SM, Gerner C. Response Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action. Chemistry – A European Journal. 2016 [Epub ahead of print]


Bileck A, Mayer RL, Kreutz D, Weiss T, Taschner-Mandl S, Meier SM, Slany A, Gerner C. Evaluation of inflammation-related signaling events covering phosphorylation and nuclear translocation of proteins based on mass spectrometry data. J Proteomics. 2016 [Epub ahead of print]


Schenk S, Krauditsch C, Frühauf P, Gerner C, Raible F. Discovery of methylfarnesoate as the annelid brain hormone reveals an ancient role of sesquiterpenoids in reproduction. eLife 2016 [Epub ahead of print]


Auer K, Bachmayr-Heyda A, Sukhbaatar N, Aust S, Schmetterer KG, Meier SM, Gerner C, Grimm C, Horvat R, Pils D. Role of the immune system in the peritoneal tumor spread of high grade serous ovarian cancer. Oncotarget. 2016 [Epub ahead of print]


Bachmayr-Heyda A, Aust S, Auer K, Meier SM, Schmetterer KG, Dekan S, Gerner C, Pils D. Integrative Systemic and Local Metabolomics with Impact on Survival in High Grade Serous Ovarian Cancer. Clin Cancer Res. 2016 [Epub ahead of print]


Sommerfeld NS, Schreiber-Brynzak E, Klose M, Bileck A, Meier SM, Gerner C, Jakupec MA, Galanski M, Keppler BK. Low generation PAMAM dendrimers as drug carriers for Pt(IV) complexes. EUrJIC. 2016 [Epub ahead of print]


Weiss T, Taschner-Mandl S, Bileck A, Slany A, Kromp F, Rifatbegovic F, Frech C, Windhager R, Kitzinger H, Tzou CH, Ambros PF, Gerner C, Ambros IM. Proteomics and transcriptomics of peripheral nerve tissue and cells unravel new aspects of the human Schwann cell repair phenotype. Glia. 2016 Aug 22


Putz EM, Majoros A, Gotthardt D, Prchal-Murphy M, Zebedin-Brandl EM, Fux Da, Schlattl A, Schreiber RD, Carotta S, Müller M, Gerner C, Decker T, Sexl V. Novel non-canonical role of STAT1 in Natural Killer cell cytotoxicity. OncoImmunology. 2016 Sep 1


Wolrab D, Frühauf P, Gerner C. Quantification oft he neurotransmitter melatonin and N-acetyl-serotonin in human serum by supercritical fluid chromatography coupled with tandem mass spectrometry. Anal Chim Acta 2016 [Epub ahead of print]


Muqaku B, Tahir A, Klepeisz P, Bileck A, Kreutz D, Mayer RL, Meier SM, Gerner M, Schmetterer K, Gerner C. Coffee consumption modulates inflammatory processes in an individual fashion. Mol Nutr Food Res. 2016 [Epub ahead of print]


Conibear AC, Farbiarz K, Mayer RL, Matveenko M, Kaehlig H, Becker CF. Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product. Org Biomol Chem. 2016 [Epub ahead of print]


Meshcheryakova A, Svoboda M, Tahir A, Köfeler HC, Triebl A, Mungenast F, Heinze G, Gerner C, Zimmermann P, Jaritz M, Mechtcheriakova D. Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach. Oncotarget. 2016 Mar 7. [Epub ahead of print]


Slany A, Bileck A, Kreutz D, Mayer RL, Muqaku B, Gerner C. Contribution of human fibroblasts and endothelial cells to the Hallmarks of Inflammation as determined by proteome profiling. Mol Cell Proteomics. 2016 Mar 29. [Epub ahead of print]  


Gschwandtner M, Paulitschke V, Mildner M, Brunner PM, Hacker S, Eisenwort G, Sperr WR, Valent P, Gerner C, Tschachler E. Proteome-analysis identifies L1CAM / CD171 and DPP4 / CD26 as novel markers of human skin mast cells. Allergy. 2016 Apr 19 [Epub ahead of print]


Šmidák R, Mayer RL, Bileck A, Gerner C, Mechtcheriakova D, Stork O, Lubec G, Li L. Quantitative proteomics reveals protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse. Behav Brain Res. 2015 Dec 31;303:208-217


Wolrab D, Frühauf P, Moulisová A, Kuchař M, Gerner C, Lindner W, Kohout M. Chiral separation of new designer drugs (Cathinones) on chiral ion-exchange type stationary phases. J Pharm Biomed Anal. 2016 Feb 20;120:306-15.  


Meier SM, Gerner C, Keppler BK, Cinellu MA, Casini A. Mass Spectrometry Uncovers Molecular Reactivities of Coordination and Organometallic Gold(III) Drug Candidates in Competitive Experiments That Correlate with Their Biological Effects. Inorg Chem. 2016 Feb 11. [Epub ahead of print]

2015

Meier SM, Muqaku B, Ullmann R, Bileck A, Kreutz D, Mader JC, Knasmüller S, Gerner C. Proteomic and Metabolomic Analyses Reveal Contrasting Anti-Inflammatory Effects of an Extract of Mucor Racemosus Secondary Metabolites Compared to Dexamethasone. PLoS One. 2015 Oct 23


Slany A, Bileck A, Muqaku B, Gerner C. Targeting breast cancer-associated fibroblasts to improve anti-cancer therapy. Breast. 2015 [Epub ahead of print]


Bileck A, Ferk F, Al-Serori H, Koller VJ, Muqaku B, Haslberger A, Auwärter V, Gerner C, Knasmüller S. Impact of a synthetic cannabinoid (CP-47,497-C8) on protein expression in human cells: evidence for induction of inflammation and DNA damage. Arch Toxicol 2015 [Epub ahead of print]


Muqaku B, Slany A, Bileck A, Kreutz D, Gerner C. Quantification of cytokines secreted by primary human cells using MRM: evaluation of analytical parameters. Anal Bioanal Chem. 2015 [Epub ahead of print]


Karlic H, Thaler R, Gerner C, Grunt T, Proestling K, Haider F, Varga F. Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells. Cancer Genet. 2015 Mar 18 [Epub ahead of print]


Kaintz C, Mayer RL, Jirsa F, Halbwirth H, Rompel A. Site-directed mutagenesis around the CuA site of a polyphenol oxidase from Coreopsis grandiflora (cgAUS1). FEBS Lett. 2015 Feb 16 [Epub ahead of print]


Molitor C, Mauracher SG, Pargan S, Mayer RL, Halbwirth H, Rompel A Latent and active aurone synthase from petals of C. grandiflora: a polyphenol oxidase with unique characteristics Planta. 2015 Feb 20 [Epub ahead of print]


Paulitschke V, Berger W, Paulitscjke P, Hofstaetter E, Knapp B, Dingelmaier-Hovorka, Födinger D, Jäger W, Szekeres T, Meshcheryakova A, Bileck A, Pirker C, Pehamberger H, Gerner C, Kunstfeld R Vemurafenib resistance signature by proteome analysis offers new strategies and rational therapeutic concepts Mol Cancer Ther. 2015 Jan 22 [Epub ahead of print]


2014

Baron DM, Kaindl U, Haudek-Prinz VJ, Bayer E, Röhrl C, Gerner C, Marian B. Autonomous inhibition of apoptosis correlates with responsiveness of colon carcinoma cell lines to ciglitazone. PLoS One. 2014 Dec 11;9(12). 


Bileck A, Kreutz D, Muqaku B, Slany A, Gerner C. Comprehensive Assessment of Proteins Regulated by Dexamethasone Reveals Novel Effects in Primary Human Peripheral Blood Mononuclear Cells. J Proteome Res. 2014 Dec 5;13(12):5989-6000.  


Paulitschke V, Gerner C, Hofstätter E, Mohr T, Mayer R, Pehamberger H, Kunstfeld R Proteome profiling of keratinocytes transforming to malignancy. Electrophoresis. 2014 Nov 14. [Epub ahead of print]  


Veitinger M, Oehler R, Umlauf E, Baumgartner R, Schmidt G, Gerner C, Babeluk R, Attems J, Mitulovic G, Rappold E, Lamont J, Zellner M. A platelet protein biochip rapidly detects an Alzheimer's disease-specific phenotype. Acta Neuropathol. 2014 Nov;128(5):665-77.  


Groessl M, Slany A, Bileck A, Gloessmann K, Kreutz D, Jaeger W, Pfeiler G, Gerner C. Proteome profiling of breast cancer biopsies reveals a wound healing signature of cancer-associated fibroblasts. J Proteome Res. 2014 Nov 7;13(11):4773-82.  


Slany A, Meshcheryakova A, Beer A, Ankersmit HJ, Paulitschke V and Gerner C Plasticity of fibroblasts demonstrated by tissue-specific and function-related proteome profiling Clinical Proteomics 2014, 11:41


Slany A, Paulitschke V, Haudek-Prinz V, Meshcheryakova A, Gerner C. Determination of cell type-specific proteome signatures of primary human leukocytes, endothelial cells, keratinocytes, hepatocytes, fibroblasts and melanocytes by comparative proteome profiling. Electrophoresis 2014, 35:1428-38.  


Zekiri F, Molitor C, Mauracher SG, Michael C, Mayer RL, Gerner C, Rompel A. Purification and characterization of tyrosinase from walnut leaves (Juglans regia). Phytochemistry. 2014, 101:5-15.  


Falsafi SK, Roßner S, Ghafari M, Groessl M, Morawski M, Gerner C, Lubec G. Changes of several brain receptor complexes in the cerebral cortex of patients with Alzheimer disease: probable new potential pharmaceutical targets. Amino Acids. 2014, 46:223-33  


Slany A, Haudek-Prinz V, Meshcheryakova A, Bileck A, Lamm W, Zielinski C, Gerner C, Drach J. Extracellular matrix remodeling by bone marrow fibroblast-like cells correlates with disease progression in multiple myeloma. J Proteome Res. 2014, 13:844-54