Univ.-Prof. Dr. Christopher Gerner
T: +43-1-4277-52302
Summer term 2020
270016 VO Mass Spectrometry - Modern instrumentation, methods and applications
270103 PR Bachelor Laboratory Course B - Analytical Chemistry and Food Chemistry
Winter term 2019
270103 PR Bachelor Laboratory Course B - Analytical Chemistry and Food Chemistry
270235 SE Seminar in Analytical Chemistry - Lecture and discussion forum of diverse topics in Analytical Chemistry


Englinger, B., Laemmerer, A., Moser, P., Kallus, S., Roehrl, C., Pirker, C., Baier, D., Mohr, T., Niederstaetter, L., Meier-Menches, S. M., Gerner, C., Gabler, L., Gojo, J., Timelthaler, G., Senkiv, J., Jaeger, W., Kowol, C. R., Heffeter, P., & Berger, W. (2020). Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib. International Journal of Cancer. https://doi.org/10.1002/ijc.32924




Distelmaier, K., Muqaku, B., Wurm, R., Arfsten, H., Seidel, S., Kovacs, G. G., Mayer, R. L., Szekeres, T., Wallisch, C., Hubner, P., Goliasch, G., Heinze, G., Heinz, G., Sterz, F., Gerner, C., & Adlbrecht, C. (2020). Proteomics-Enriched Prediction Model for Poor Neurologic Outcome in Cardiac Arrest Survivors*. Critical Care Medicine, 48(2), 167-175. https://doi.org/10.1097/CCM.0000000000004105


Heudobler, D., Lueke, F., Vogelhuber, M., Klobuch, S., Pukrop, T., Herr, W., Gerner, C., Pantziarka, P., Ghibelli, L., & Reichle, A. (2019). Anakoinosis: Correcting Aberrant Homeostasis of Cancer Tissue-Going Beyond Apoptosis Induction. Frontiers in Oncology, 9, [1408]. https://doi.org/10.3389/fonc.2019.01408



Slany, A., Wagner, R., Stübiger, G., Semkova, M., Colomer, R., López-Rodríguez, M. L., Gerner, C., & Grunt, T. W. (2019). Hit one to eliminate all during cancer treatment: The crucial role of fatty acid synthase (FASN) in ovarian cancer (OC) growth. In JNTERNATIONAL JOURNAL OF MOLECULAR MEDICINE: Proceedings of the Abstracts of The 24th World Congress on Advances in Oncology and 24th International Symposium on Molecular Medicine (Vol. 44, pp. 7)


Paulitschke, V., Eichhoff, O., Gerner, C., Paulitschke, P., Bileck, A., Mohr, T., Cheng, P. F., Leitner, A., Guenova, E., Saulite, I., Freiberger, S. N., Irmisch, A., Knapp, B., Zila, N., Chatziisaak, T-P., Stephan, J., Mangana, J., Kunstfeld, R., Pehamberger, H., ... Levesque, M. P. (2019). Proteomic identification of a marker signature for MAPKi resistance in melanoma. EMBO Journal, 38(15), [95874]. https://doi.org/10.15252/embj.201695874




Kreutz, D., Gerner, C., & Meier-Menches, S. M. (2019). Enabling Methods to Elucidate the Effects of Metal-based Anticancer Agents. In A. Vessieres, S. M. Meier-Menches, & A. Casini (Eds.), Metal-based Anticancer Agents (pp. 246-270). Royal Society of Chemistry. RSC Metallobiology, No. 14, Vol.. 2019-January https://doi.org/10.1039/9781788016452-00246

Schuster, D., Janker, L., Pfisterer, N., Redl, E., Slany, A., Feichtenschlager, T., & Gerner, C. (2019). Contribution of inflamed fibroblasts to the disease phenotype of ulcerative colitis. Poster session presented at Proteomics and its Application to Translational and Precision Medicine (D3), Stockholm, Sweden.

Slany, A., Janker, L., Mayer, R. L., Bileck, A., Kreutz, D., Mader, J., Utpatel, K., Heudobler, D., Agis, H., & Gerner, C. (2019). An in-depth proteome profiling analysis of primary human myeloma cells shows that adaptations to hypoxia are associated with multiple myeloma disease progression. Poster session presented at Proteomics in Cell Biology and Disease Mechanisms, Heidelberg, Germany.

Curriculum vitae
Prof. Dr. Christopher Gerner
Current positions:
• Debuty head of the Department of Analytical Chemistry
• Deputy head of the Centre for Mass Spectrometry at the Faculty of Chemistry
• Deputy head of the Research Platform "Marine Rhythms of Life"
• Deputy head of the Karl Landsteiner Institute of Bioanalytical Oncology
Higher education:
2002 Venia docendi for Oncologic Biochemistry, University of Vienna
1998 PhD for Biochemistry at University of Vienna
1993 MSc for Chemistry at University of Vienna
Academic appointments and professional experience:
Since 2012 Full Professor for Separation Technologies and Bioanalysis at University of Vienna
2009 Visiting Scientist at the Diamantine Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Australia
2003-2012 Group leader of the Clinical Proteomics Laboratories at the Medical University of Vienna
2002 Post-Doc in the group of Prof. Seamus Martin, Trinity College, Dublin, Ireland
2001 Visiting scientist in the group of Prof. Gerald Cohen, University of Leicester, GB.
1998-2001 Post-Doc in the group of Prof. Rolf Schulte-Hermann, Department of Toxicology, University of Vienna
1997 UN Officer (degree: Major) and Acting Chief Inspector for Chemical Team at UNSCOM, Baghdad, Iraq
1995-1998 Research Assistant at the Institute of Cancer Research, Vienna
Research activities
Bioanalysis largely based on various forms of chromatography hyphenated with mass spectrometry focussing on the development of novel methods for investigating patho-mechanisms and drug effects in humans. A combined analysis of proteins, lipids and metabolites is applied for providing new insights into processes such as inflammation, cancer and tissue regeneration. New methods are established supporting easy and reliable sampling of human individuals such as fingersweat analyses for individual profiling.
Key papers
1. Muqaku, B.; Eisinger, M.; Meier, S. M.; Tahir, A.; Pukrop, T.; Haferkamp, S.; Slany, A.; Reichle, A.; Gerner, C., Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma. Mol Cell Proteomics 2017, 16, (1), 86-99.
2. Tahir, A.; Bileck, A.; Muqaku, B.; Niederstaetter, L.; Kreutz, D.; Mayer, R. L.; Wolrab, D.; Meier, S. M.; Slany, A.; Gerner, C., Combined Proteome and Eicosanoid Profiling Approach for Revealing Implications of Human Fibroblasts in Chronic Inflammation. Anal Chem 2017, 89, (3), 1945-1954.
3. Kreutz, D.; Bileck, A.; Plessl, K.; Wolrab, D.; Groessl, M.; Keppler, B. K.; Meier, S. M.; Gerner, C., Response Profiling Using Shotgun Proteomics Enables Global Metallodrug Mechanisms of Action To Be Established. Chemistry 2017, 23, (8), 1881-1890.

Mass spectrometry-based analysis of peptides from human tooth enamel: a new perspective for archaeological and anthropological studies

Lukas Janker (Invited speaker), Katharina Rebay-Salisbury (Contributor), Christopher Gerner (Contributor)
21 Jan 2020

Activity: Talks and presentationsTalk or oral contributionScience to Science


Molecular profiling of cutaneous melanoma cells and their cerebral metastasis from patient derived mouse xenografts suggest individually distinct adaptation strategies

Benjamin Neuditschko (Speaker), Lukas Janker (Contributor), Laura Niederstätter (Contributor), Julia Brunmair (Contributor), Katharina Krivanek (Contributor), Sivan Izraely (Contributor), Orit Sagi-Assif (Contributor), Tsipi Meshel (Contributor), Bernhard Keppler (Contributor), Giorgia Del Favero (Contributor), Isaac P. Witz (Contributor), Christopher Gerner (Contributor)
23 Sep 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


Combination of proteome profiling with mechanotransduction: expanding the knowledge about melanoma metastasis

Giorgia Del Favero (Speaker), Benjamin Neuditschko (Contributor), Katharina Krivanek (Contributor), Lukas Janker (Contributor), Sivan Izraely (Contributor), Orit Sagi-Assif (Contributor), Tsipi Meshel (Contributor), Isaac P. Witz (Contributor), Christopher Gerner (Contributor)
20 Sep 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


Multi-omic patterns in body fluids: Technological challenge with a great potential to implement the advanced paradigm of 3P Medicine

Christopher Gerner (Keynote speaker)
19 Sep 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


Identifying key players responsible for local and systemic changes in colonic tissue and plasma samples of ulcerative colitis patients

Lukas Janker (Speaker), Dina Schuster (Contributor), Laura Niederstätter (Contributor), Nikolaus Pfisterer (Contributor), Astrid Slany (Contributor), Thomas Feichtenschlager (Contributor), Christopher Gerner (Contributor)
18 Sep 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


Proteomic profiling reveals molecular cell responses to deoxynivalenol treatment in human A431 epidermoid squamous carcinoma cells

Giorgia Del Favero (Speaker), Lukas Janker (Contributor), Benjamin Neuditschko (Contributor), Julia Hohenbichler (Contributor), Lydia Wölflingseder (Contributor), Christopher Gerner (Contributor), Doris Marko (Contributor)
25 Apr 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


Deoxynivalenol and A431 epidermoid squamous carcinoma cells: proteomic profiling reveals the pathways connecting ribosomal inhibition with a loss of function of the cell membrane

Lukas Janker (Speaker), Benjamin Neuditschko (Speaker), Julia Hohenbichler (Contributor), Lydia Wölflingseder (Contributor), Christopher Gerner (Contributor), Doris Marko (Contributor), Giorgia Del Favero (Contributor)
19 Feb 2019

Activity: Talks and presentationsTalk or oral contributionScience to Science


Eicosanoids as underestimated molecular players relevant for tumor biology and mechanisms of metastasis

Lukas Janker (Invited speaker), Laura Niederstätter (Contributor), Benjamin Neuditschko (Contributor), Julia Brunmair (Contributor), Samuel Matthias Meier-Menches (Contributor), Christopher Gerner (Contributor)
6 Dec 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Metabolomics, lipidomics and proteomics unravel the role of neutrophils for ovarian cancer and melanoma metastases

Christopher Gerner (Invited speaker)
6 Dec 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Cold induced eicosanoid signature differs between BAT positive and BAT negative subjects

Laura Niederstätter (Speaker), Oana C. Hedesan (Contributor), Carsten Herz (Contributor), Alexander R. Haug (Contributor), Christopher Gerner (Contributor), Florian W. Kiefer (Contributor)
29 Aug 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


In-depth proteome profiling of primary human myeloma cells: new insights into hypoxia driven metabolic, anti-apoptotic and immune evasion strategies

Astrid Slany (Speaker), Lukas Janker (Contributor), Rupert Laurenz Mayer (Contributor), Andrea Bileck (Contributor), Dominique Kreutz (Contributor), Johanna Mader (Contributor), Hermine Agis (Contributor), Christopher Gerner (Contributor)
29 Aug 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Unravelling the effect of deoxynivalenol on A431 cells: Proteome profiling and imaging

Giorgia Del Favero (Speaker), Lukas Janker (Contributor), Benjamin Neuditschko (Contributor), Lydia Wölflingseder (Contributor), Christopher Gerner (Contributor), Doris Marko (Contributor)
6 Jul 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


The power of integrative multi-omics analyses for diagnostic and prognostic purposes

Christopher Gerner (Invited speaker)
24 May 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Curcumin exerts its antitumor effects in a context dependent fashion

Lukas Janker (Speaker), Dominique Kreutz (Contributor), Chomdao Sinthuvanich (Contributor), Andrea Bileck (Contributor), Astrid Slany (Contributor), Christopher Gerner (Contributor)
4 May 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Evaluation of individual metabolic parameters by the analysis of finger sweat samples using liquid chromatography‐mass spectrometry

Julia Brunmair (Speaker), Christopher Gerner (Contributor), Laura Niederstätter (Contributor)
4 May 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Image analysis and proteomic profiling: complementary tools for toxicity studies

Giorgia Del Favero (Speaker), Lydia Wölflingseder (Contributor), Lukas Janker (Contributor), Benjamin Neuditschko (Contributor), Christopher Gerner (Contributor), Doris Marko (Contributor)
4 May 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Response Profiling of the anti‐cancer drug arsenic trioxide

Benjamin Neuditschko (Speaker), Christopher Gerner (Contributor)
4 May 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Integrative Metabolomics with Impact on Survival in Serous Ovarian Cancer

Christopher Gerner (Speaker)
19 Apr 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia

Christopher Gerner (Invited speaker)
21 Mar 2018

Activity: Talks and presentationsTalk or oral contributionScience to Science


Aging-related proteome alterations in B cells may predispose for chronic lymphocytic leukemia

Rupert Laurenz Mayer (Speaker), Astrid Slany (Contributor), Andrea Bileck (Contributor), Johanna Mader (Contributor), Samuel Matthias Meier (Contributor), Tobias Pukrop (Contributor), Albrecht Reichle (Contributor), Josef D. Schwarzmeier (Contributor), Christopher Gerner (Contributor)
6 Sep 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma

Besnik Muqaku (Speaker), Martin Eisinger (Contributor), Samuel Matthias Meier (Contributor), Ammar Tahir (Contributor), Tobias Pukrop (Contributor), Sebastian Haferkamp (Contributor), Astrid Slany (Contributor), Albrecht Reichle (Contributor), Christopher Gerner (Contributor)
6 Sep 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


On the molecular mechanism of action of organometallic anticancer drugs

Christopher Gerner (Speaker), Samuel Matthias Meier (Contributor), Dominique Kreutz (Contributor), Tamara Weiss (Contributor), Andrea Bileck (Contributor), Bernhard Keppler (Contributor), Gerhard Wiche (Contributor)
14 Aug 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


The amazing functional plasticity of platelets investigated by combining proteomics with lipidomics

Christopher Gerner (Speaker)
10 Apr 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Combinatory shotgun proteomics and shotgun eicosadomics study of platelets activated by calcium mobilization

Christopher Gerner (Speaker), Ammar Tahir (Contributor), Rupert Laurenz Mayer (Contributor), Marie L. Boehm (Contributor), Andrea Bileck (Contributor), Besnik Muqaku (Contributor), Albrecht Reichle (Contributor), Astrid Slany (Contributor)
3 Apr 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Combined proteomics and lipidomics supports the investigation and discovery of novel pathomechanisms

Christopher Gerner (Speaker)
12 Jan 2017

Activity: Talks and presentationsTalk or oral contributionScience to Science


Proteomics for Understanding Metallodrug Effects

Samuel Matthias Meier-Menches (Invited speaker), Dominique Kreutz (Contributor), Bernhard Keppler (Contributor), Christopher Gerner (Contributor)
4 Dec 2016

Activity: Talks and presentationsTalk or oral contributionScience to Science




Comprehension of cancer disease mechanisms by the combination of proteomics, lipidomics and metabolomics

Christopher Gerner (Speaker)
4 Nov 2016

Activity: Talks and presentationsTalk or oral contributionOther


Relating eicosanoid formation with cytokine secretion offers new insight into the regulation of inflammatory processes

Christopher Gerner (Invited speaker)
14 Oct 2016

Activity: Talks and presentationsTalk or oral contributionOther


Metabolomics of Fingersweat: Individual Assessment of Metabolic Parameters based on Fingerprint Analyses

Christopher Gerner (Invited speaker)
12 Sep 2016

Activity: Talks and presentationsTalk or oral contributionOther


Metabolomics of Fingersweat: Individual Assessment of Metabolic Parameters based on Fingerprint Analyses

Christopher Gerner (Keynote speaker)
12 Sep 2016

Activity: Talks and presentationsTalk or oral contributionOther


Proteomics for Understanding Metallodrug Effects

Samuel Matthias Meier-Menches (Speaker), Christopher Gerner (Contributor)
5 Sep 2016

Activity: Talks and presentationsTalk or oral contributionScience to Science


Was ist das? – Alte und neue Methoden der Analytik

Christopher Gerner (Invited speaker)
10 May 2016

Activity: Talks and presentationsTalk or oral contributionOther


Tumor-stroma interactions investigated by proteomics and metabolomics

Christopher Gerner (Speaker)
7 Mar 2016

Activity: Talks and presentationsTalk or oral contributionOther



Can we improve the accuracy of measurements of small molecules in biological samples using multi-omics approaches?

Christopher Gerner (Invited speaker)
20 Nov 2015

Activity: Talks and presentationsTalk or oral contributionOther



Proteome analyses of serum of patients with metastatic melanoma

Christopher Gerner (Invited speaker)
30 Sep 2015

Activity: Talks and presentationsTalk or oral contributionOther


Proteome signatures of inflammatory primary human mesenchymal cells

Christopher Gerner (Speaker)
20 Jul 2015

Activity: Talks and presentationsTalk or oral contributionOther


Investigation of anticancer drug effects via proteome and metabolome profiling: do we really understand what these drugs are doing?

Christopher Gerner (Keynote speaker)
2 Jul 2015

Activity: Talks and presentationsTalk or oral contributionOther


LC-MS basierende Analysen von Eicosanoiden und anderen relevanten Entzündungsmediatoren in primären menschlichen Zellmodellen

Christopher Gerner (Invited speaker)
5 Dec 2014

Activity: Talks and presentationsTalk or oral contributionOther


Schwannomics: Profiling Schwann cells as potential prototype for tumor-inhibiting stromal cells

Christopher Gerner (Speaker)
24 Sep 2014

Activity: Talks and presentationsTalk or oral contributionOther


Cell type-specific secretome profiles obtained from inflammatory stimulated primary human cells can be used for drug evaluation

Christopher Gerner (Keynote speaker)
17 Sep 2014

Activity: Talks and presentationsTalk or oral contributionOther



Schwann cells: shedding new light on old players in tumor biology

Christopher Gerner (Invited speaker)
2 Apr 2014

Activity: Talks and presentationsTalk or oral contributionOther


HRMS and MRM based quantitative secretome analysis – a key for assessing cell functions and drug effects

Christopher Gerner (Speaker)
19 Feb 2014

Activity: Talks and presentationsTalk or oral contributionOther


Evaluation of tumor-suppressive and tumor-promoting stroma cell activities by proteome profiling focussing on secretome analyses

Christopher Gerner (Invited speaker)
5 Feb 2014

Activity: Talks and presentationsTalk or oral contributionOther


Evaluation of tumor-suppressive and tumor-promoting stroma cell activities by proteome profiling focussing on secretome analyses

Christopher Gerner (Invited speaker)
5 Feb 2014

Activity: Talks and presentationsTalk or oral contributionOther


Comprehension of complex biological processes by analytical methods: how far can we go using mass spectrometry?

Christopher Gerner (Invited speaker)
5 Dec 2013

Activity: Talks and presentationsTalk or oral contributionOther


Erhöhtes Krebsrisiko im Alter durch chronisch entzündlich stimulierte Bindegewebszellen

Christopher Gerner (Speaker)
27 Nov 2013

Activity: Talks and presentationsTalk or oral contributionOther



Testing drug effects by secretome profiling with the aim to interfere with stroma-derived tumor promotion

Christopher Gerner (Invited speaker)
19 Nov 2013

Activity: Talks and presentationsTalk or oral contributionOther


Proteome profiling of inflammatory processes and the effects of antiphlogistic drugs on leukocytes and stroma cells

Christopher Gerner (Invited speaker)
3 Oct 2013

Activity: Talks and presentationsTalk or oral contributionOther


Investigation of drug effects by the combination of proteomics and lipidomics

Christopher Gerner (Speaker)
2 Sep 2013

Activity: Talks and presentationsTalk or oral contributionOther


Understanding tumour-stroma interactions by the systematic proteome profiling of primary human cells

Christopher Gerner (Invited speaker)
2 Aug 2013

Activity: Talks and presentationsTalk or oral contributionOther


In depth proteomics profiling of inflammatory activated human cells

Christopher Gerner (Invited speaker)
1 Aug 2013

Activity: Talks and presentationsTalk or oral contributionOther


Comprehensive proteomics profiling combined with targeted proteomics: new avenues for biomarker discovery

Christopher Gerner (Invited speaker)
8 Mar 2013

Activity: Talks and presentationsTalk or oral contributionOther


How can we make proteome analysis data more reliable?

Christopher Gerner (Invited speaker)
19 Feb 2013

Activity: Talks and presentationsTalk or oral contributionOther


QQQ-basierende Quantifizierung von Biomarker-Kandidaten aus Blutserum: Wie nahe sind wir jetzt an der klinischen Einsetzbarkeit?"

Christopher Gerner (Invited speaker)
13 Feb 2013

Activity: Talks and presentationsTalk or oral contributionOther


Quantitative analysis of glycoconjugates in the context of biomarker research

Christopher Gerner (Contributor)
30 Nov 2012

Activity: Talks and presentationsTalk or oral contributionOther


Systematische Sekretomanalysen zur Charakterisierung neuer Tumormarker

Christopher Gerner (Invited speaker)
9 Nov 2012

Activity: Talks and presentationsTalk or oral contributionOther


TARGETED PROTEOMICS APPROACHES FOR MONITORING CYTOKINE SECRETION FOLLOWING INFLAMMATORY STIMULATION

Christopher Gerner (Contributor)
14 Oct 2012

Activity: Talks and presentationsTalk or oral contributionOther


Characterization of tumor-stroma interactions by means of marker proteins in multiple myeloma

Christopher Gerner (Contributor)
24 Sep 2012

Activity: Talks and presentationsTalk or oral contributionOther


HPLC-MS/MS Analysis of Glycoconjugates in the Context of Biomarker Research

Christopher Gerner (Contributor)
11 Jun 2012

Activity: Talks and presentationsTalk or oral contributionOther


Dissecting Temporal Metallodrug Effects in Cancer Cells

Samuel Matthias Meier-Menches (Speaker), Christopher Gerner (Contributor)
30 Jun 2010

Activity: Talks and presentationsTalk or oral contributionScience to Science


Dissecting Temporal Metallodrug Effects in Cancer Cells

Samuel Matthias Meier-Menches (Speaker), Christopher Gerner (Contributor)
30 Jun 2010

Activity: Talks and presentationsTalk or oral contributionScience to Science


Department of Analytical Chemistry

Head

Währinger Straße 38
1090 Wien
Room: 1220

T: +43-1-4277-52302
F: +43-1-4277-852302

christopher.gerner@univie.ac.at