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Univ.-Prof. Dr. Christopher Gerner

T: +43-1-4277-52302

christopher.gerner@univie.ac.at

Winter term 2024

270005 VO Analytical Chemistry II

270010 VO Mass Spectrometry I

270013 SE Writing of the Bachelor´s Thesis

270094 VU Basic Concepts of the Natural Sciences

270101 UE Practice in Analytical Chemistry

270103 PR Bachelor Laboratory Course B - Analytical Chemistry and Food Chemistry

270193 VO Sample Preparation Techniques

270244 PR Mass Spectrometry I

270248 VO Proteomics

270251 VU Evaluation Strategies of Big Data

301417 VO Methods in Molecular Biology

Summer term 2024

270013 SE Writing of the Bachelor´s Thesis

270027 VO Mass Spectrometry - Modern instrumentation, methods and applications

270044 PR Multiomics analysis strategies

270052 VO Analytical Chemistry I

270101 UE Practice in Analytical Chemistry

270103 PR Bachelor Laboratory Course B - Analytical Chemistry and Food Chemistry

270198 VO Bioinformatics I

530017 SE Bioanalysis and Translational Research

Winter term 2023

270006 VO Analytical Chemistry II

270013 SE Writing of the Bachelor´s Thesis

270035 VO Mass Spectrometry I

270101 UE Practice in Analytical Chemistry

270103 PR Bachelor Laboratory Course B - Analytical Chemistry and Food Chemistry

270193 VO Sample Preparation Techniques

270244 PR Mass Spectrometry I

270248 VO Proteomics

270251 VU Evaluation Strategies of Big Data

301417 VO Methods in Molecular Biology

530017 SE Bioanalysis and Translational Research

Elkhamary, A., Gerner, I., Bileck, A., Oreff, G. L., Gerner, C., & Jenner, F. (2024). Comparative proteomic profiling of the ovine and human PBMC inflammatory response. Scientific Reports, 14(1), Article 14939. https://doi.org/10.1038/s41598-024-66059-0

Koenig, C., Janker-Bortel, P., Paterson, R. S., Rendl, B., Madupe, P. P., Troché, G. B., Hermann, N. V., Martínez de Pinillos, M., Martinón-Torres, M., Mularczyk, S., Schjellerup Jørkov, M. L., Gerner, C., Kanz, F., Martinez-Val, A., Cappellini, E., & Olsen, J. V. (2024). Automated High-Throughput Biological Sex Identification from Archeological Human Dental Enamel Using Targeted Proteomics. Journal of Proteome Research, 23(11), 5107-5121. https://doi.org/10.1021/acs.jproteome.4c00557

Jobst, M., Crudo, F., Di Franco, J., Marko, D., Cerbino, R., Gerner, C., & Del Favero, G. (2024). Bafilomycin induces mitochondrial reorganization, nuclear deformation and γH2AX increase in T24 bladder cancer cells. Toxicology Letters, 399(Supplement 2), S223-S223. Article Meeting AbstractP13-32. https://doi.org/10.1016/j.toxlet.2024.07.548

Hagn, G., Meier-Menches, S. M., Plessl-Walder, G., Mitra, G., Mohr, T., Preindl, K., Schlatter, A., Schmidl, D., Gerner, C., Garhöfer, G., & Bileck, A. (2024). Plasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets. Journal of Proteome Research, 23(8), 3064-3075. https://doi.org/10.1021/acs.jproteome.3c00761

Wimmer, B., Schernthaner, J., Edobor, G., Friedrich, A., Poeltner, K., Temaj, G., Wimmer, M., Kronsteiner, E., Pichler, M., Gercke, H., Huber, R., Kaefer, N., Rinnerthaler, M., Karl, T., Krauß, J., Mohr, T., Gerner, C., Hintner, H., Breitenbach, M., ... Breitenbach-Koller, H. (2024). RiboScreen^TM Technology Delivers a Ribosomal Target and a Small-Molecule Ligand for Ribosome Editing to Boost the Production Levels of Tropoelastin, the Monomeric Unit of Elastin. International Journal of Molecular Sciences, 25(15), Article 8430. https://doi.org/10.3390/ijms25158430

Skos, L., Schmidt, C., Thomas, S. R., Park, M., Geiger, V., Wenisch, D., Bonsignore, R., Del Favero, G., Mohr, T., Bileck, A., Gerner, C., Casini, A., & Meier-Menches, S. M. (2024). Gold-templated covalent targeting of the CysSec-dyad of thioredoxin reductase 1 in cancer cells. Cell Reports Physical Science, 5(7), Article 102072. https://doi.org/10.1016/j.xcrp.2024.102072

Janker-Bortel, P., Hagn, G., Skos, L., Bileck, A., Paulitschke, V., Paulitschke, P., Gleiter, L., Mohr, T., Gerner, C., & Meier-Menches, S. M. (2024). Memory effects of prior subculture may impact the quality of multiomic perturbation profiles. Proceedings of the National Academy of Sciences of the United States of America, 121(29), Article e2313851121. https://doi.org/10.1073/pnas.2313851121

Peyrl, A., Hagn, G., Stepien, N., Senfter, D., Madlener, S., Sterba, J., Lassaletta, A., Leblond, P., Nysom, K., Haberler, C., Bileck, A., Azizi, A., Mayr, L., Gojo, J., Slavc, I., & Gerner, C. (2024). MDB-36. 22-HDOHE, A PREDICTIVE MARKER IN CSF OF PATIENTS WITH RECURRENT MEDULLOBLASTOMA TREATED WITH MEMMAT. Neuro-Oncology, 26(Suppl. 4), Article NOAE064485. https://doi.org/10.1093/neuonc/noae064.485

Janker-Bortel, P., Piga, I., Koenig, C., Gerner, C., Martinez-Val, A., & Olsen, J. V. (2024). Systematic Optimization of Automated Phosphopeptide Enrichment for High-Sensitivity Phosphoproteomics. Molecular and Cellular Proteomics, 23(5), Article 100754. https://doi.org/10.1016/j.mcpro.2024.100754

Pai, V., Bileck, A., Hommer, N., Janku, P., Lindner, T., Kauer, V., Rumpf, B., Haslacher, H., Hagn, G., Meier-Menches, S. M., Schmetterer, L., Schmidl, D., Gerner, C., & Garhöfer, G. (2024). Impaired retinal oxygen metabolism and perfusion are accompanied by plasma protein and lipid alterations in recovered COVID-19 patients. Scientific Reports, 14(1), Article 8395. https://doi.org/10.1038/s41598-024-56834-4

Tarasova, K., Arteaga, M. B., Kidtiwong, A., Nivarthi, H., Gamauf, J., Gultekin, S., Gerner, I., Hackl, M., Gerner, C., Grillari, R., & Jenner, F. (2024). THERAPEUTIC POTENTIAL OF PERINATAL MESENCHYMAL STROMAL CELLS DERIVED EXTRACELLULAR VESICLES ON INFLAMED CHONDROCYTES IN VITRO. Osteoarthritis and Cartilage, 32(Suppl 1), S318-S319. Article Meeting Abstract: 456.

Arteaga, M. B., Tarasova, K., Kidtiwong, A., Gultekin, S., Hackl, M., Gerner, I., Gerner, C., & Jenner, F. (2024). UNDERSTANDING THE DUAL EFFECTS OF DEXAMETHASONE ON CHONDROCYTES: FROM ANTI-INFLAMMATORY POTENCY TO PREMATURE SENESCENCE INDUCTION. Osteoarthritis and Cartilage, 32(Suppl 1), S594-S594. Article Meeting Abstract: 864.

Zott, T., Bileck, A., Plessl-Walder, G., Gerner, C., & Silberhumer, G. (2024). Resistance to Chemo Radiation in Rectal Cancer Can Potentially be Predicted by Proteomic Analyses. Annals of Surgical Oncology, 31(Supplement 1), S53-S54.

Zila, N., Eichhoff, O. M., Steiner, I., Mohr, T., Bileck, A., Cheng, P. F., Leitner, A., Gillet, L., Sajic, T., Goetze, S., Friedrich, B., Janker-Bortel, P., Strobl, J., Reitermaier, R., Hogan, S. A., Martínez Gómez, J. M., Staeger, R., Tuchmann, F., Peters, S., ... Paulitschke, V. (2024). Proteomic Profiling of Advanced Melanoma Patients to Predict Therapeutic Response to Anti-PD-1 Therapy. Clinical Cancer Research, 30(1), 159-175. https://doi.org/10.1158/1078-0432.CCR-23-0562

Karasová, M., Framke, D., Gerner, C., & Del Favero, G. (2024). Exploring pathways for mechan/cal-drlven tumor promotion and chemoresistance in ovarian cancer cells. Naunyn-Schmiedeberg's Archives of Pharmacology, 397(Suppl.1), S38-S39. Article P088.

Hohagen, M., Saraiva, N., Kählig, H., Gerner, C., Del Favero, G., & Kleitz, F. (2024). Silica nanoparticle conjugation with gallic acid towards enhanced free radical scavenging capacity and activity on osteosarcoma cells in vitro. Journal of Materials Chemistry B, 12(26), 6424-6441. Advance online publication. https://doi.org/10.1039/d4tb00151f

Ries, A., Flehberger, D., Slany, A., Pirker, C., Mader, J. C., Mohr, T., Schelch, K., Sinn, K., Mosleh, B., Hoda, M. A., Dome, B., Dolznig, H., Krupitza, G., Müllauer, L., Gerner, C., Berger, W., & Grusch, M. (2023). Mesothelioma-associated fibroblasts enhance proliferation and migration of pleural mesothelioma cells via c-Met/PI3K and WNT signaling but do not protect against cisplatin. Journal of Experimental and Clinical Cancer Research, 42(1), Article 27. https://doi.org/10.1186/s13046-022-02582-0

Fetahu, I. S., Esser-Skala, W., Dnyansagar, R., Sindelar, S., Rifatbegovic, F., Bileck, A., Skos, L., Bozsaky, E., Lazic, D., Shaw, L., Tötzl, M., Tarlungeanu, D., Bernkopf, M., Rados, M., Weninger, W., Tomazou, E. M., Bock, C., Gerner, C., Ladenstein, R., ... Taschner-Mandl, S. (2023). Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis. Nature Communications, 14(1), Article 3620. https://doi.org/10.1038/s41467-023-39210-0

Borutzki, Y., Skos, L., Gerner, C., & Meier-Menches, S. M. (2023). Exploring the Potential of Metal-Based Candidate Drugs as Modulators of the Cytoskeleton. ChemBioChem, 24(17), Article e202300178. https://doi.org/10.1002/cbic.202300178

Janker, L., Schuster, D., Bortel, P., Hagn, G., Meier-Menches, S. M., Mohr, T., Mader, J. C., Slany, A., Bileck, A., Brunmair, J., Madl, C., Unger, L., Hennlich, B., Weitmayr, B., Del Favero, G., Pils, D., Pukrop, T., Pfisterer, N., Feichtenschlager, T., & Gerner, C. (2023). Multi-omics empowered deep phenotyping of ulcerative colitis identifies biomarker signatures reporting functional remission states. Journal of Crohn's & colitis, 17(9), 1514-1527. https://doi.org/10.1093/ecco-jcc/jjad052

Curriculum vitae
Prof. Dr. Christopher Gerner
Current positions:
• Debuty head of the Department of Analytical Chemistry
• Deputy head of the Centre for Mass Spectrometry at the Faculty of Chemistry
• Deputy head of the Research Platform "Marine Rhythms of Life"
• Deputy head of the Karl Landsteiner Institute of Bioanalytical Oncology
Higher education:
2002 Venia docendi for Oncologic Biochemistry, University of Vienna
1998 PhD for Biochemistry at University of Vienna
1993 MSc for Chemistry at University of Vienna
Academic appointments and professional experience:
Since 2012 Full Professor for Separation Technologies and Bioanalysis at University of Vienna
2009 Visiting Scientist at the Diamantine Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Australia
2003-2012 Group leader of the Clinical Proteomics Laboratories at the Medical University of Vienna
2002 Post-Doc in the group of Prof. Seamus Martin, Trinity College, Dublin, Ireland
2001 Visiting scientist in the group of Prof. Gerald Cohen, University of Leicester, GB.
1998-2001 Post-Doc in the group of Prof. Rolf Schulte-Hermann, Department of Toxicology, University of Vienna
1997 UN Officer (degree: Major) and Acting Chief Inspector for Chemical Team at UNSCOM, Baghdad, Iraq
1995-1998 Research Assistant at the Institute of Cancer Research, Vienna
Research activities
Bioanalysis largely based on various forms of chromatography hyphenated with mass spectrometry focussing on the development of novel methods for investigating patho-mechanisms and drug effects in humans. A combined analysis of proteins, lipids and metabolites is applied for providing new insights into processes such as inflammation, cancer and tissue regeneration. New methods are established supporting easy and reliable sampling of human individuals such as fingersweat analyses for individual profiling.
Key papers
1. Muqaku, B.; Eisinger, M.; Meier, S. M.; Tahir, A.; Pukrop, T.; Haferkamp, S.; Slany, A.; Reichle, A.; Gerner, C., Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma. Mol Cell Proteomics 2017, 16, (1), 86-99.
2. Tahir, A.; Bileck, A.; Muqaku, B.; Niederstaetter, L.; Kreutz, D.; Mayer, R. L.; Wolrab, D.; Meier, S. M.; Slany, A.; Gerner, C., Combined Proteome and Eicosanoid Profiling Approach for Revealing Implications of Human Fibroblasts in Chronic Inflammation. Anal Chem 2017, 89, (3), 1945-1954.
3. Kreutz, D.; Bileck, A.; Plessl, K.; Wolrab, D.; Groessl, M.; Keppler, B. K.; Meier, S. M.; Gerner, C., Response Profiling Using Shotgun Proteomics Enables Global Metallodrug Mechanisms of Action To Be Established. Chemistry 2017, 23, (8), 1881-1890.