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Ass.-Prof. Dr. Samuel Matthias Meier-Menches, Privatdoz. BSc MSc

T: +43-1-4277-52373

samuel.meier-menches@univie.ac.at

meiermencheslab.univie.ac.at

Winter term 2024

270013 SE Writing of the Bachelor´s Thesis

270077 PR Basic Laboratory Course II A

270101 UE Practice in Analytical Chemistry

270103 PR Bachelor Laboratory Course B - Analytical Chemistry and Food Chemistry

270251 VU Evaluation Strategies of Big Data

530017 SE Bioanalysis and Translational Research

Summer term 2024

270013 SE Writing of the Bachelor´s Thesis

270077 PR Basic Laboratory Course II A

270103 PR Bachelor Laboratory Course B - Analytical Chemistry and Food Chemistry

270189 PR Metabolic Phenotyping

270297 VO Receptor Ligand Interactions

950133 VO General and applied biochemistry

Winter term 2023

270013 SE Writing of the Bachelor´s Thesis

270077 PR Basic Laboratory Course II A

270101 UE Practice in Analytical Chemistry

270103 PR Bachelor Laboratory Course B - Analytical Chemistry and Food Chemistry

Hagn, G., Meier-Menches, S. M., Plessl-Walder, G., Mitra, G., Mohr, T., Preindl, K., Schlatter, A., Schmidl, D., Gerner, C., Garhöfer, G., & Bileck, A. (2024). Plasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets. Journal of Proteome Research, 23(8), 3064-3075. https://doi.org/10.1021/acs.jproteome.3c00761

Skos, L., Schmidt, C., Thomas, S. R., Park, M., Geiger, V., Wenisch, D., Bonsignore, R., Del Favero, G., Mohr, T., Bileck, A., Gerner, C., Casini, A., & Meier-Menches, S. M. (2024). Gold-templated covalent targeting of the CysSec-dyad of thioredoxin reductase 1 in cancer cells. Cell Reports Physical Science, 5(7), Article 102072. https://doi.org/10.1016/j.xcrp.2024.102072

Janker-Bortel, P., Hagn, G., Skos, L., Bileck, A., Paulitschke, V., Paulitschke, P., Gleiter, L., Mohr, T., Gerner, C., & Meier-Menches, S. M. (2024). Memory effects of prior subculture may impact the quality of multiomic perturbation profiles. Proceedings of the National Academy of Sciences of the United States of America, 121(29), Article e2313851121. https://doi.org/10.1073/pnas.2313851121

Pai, V., Bileck, A., Hommer, N., Janku, P., Lindner, T., Kauer, V., Rumpf, B., Haslacher, H., Hagn, G., Meier-Menches, S. M., Schmetterer, L., Schmidl, D., Gerner, C., & Garhöfer, G. (2024). Impaired retinal oxygen metabolism and perfusion are accompanied by plasma protein and lipid alterations in recovered COVID-19 patients. Scientific Reports, 14(1), Article 8395. https://doi.org/10.1038/s41598-024-56834-4

Long, D., Eade, L., Sullivan, M. P., Dost, K., Meier-Menches, S. M., Goldstone, D. C., Hartinger, C. G., Wicker, J. S., & Taškova, K. (2024). AdductHunter: identifying protein-metal complex adducts in mass spectra. Journal of Cheminformatics, 16(1), Article 15. https://doi.org/10.1186/s13321-023-00797-7

Borutzki, Y., Meier-Menches, S. M., McNamara , L. E., & Anderson, J. S. (2024). Investigating biological effects of a novel organometallic complex as potential theranostic agent. Naunyn-Schmiedeberg's Archives of Pharmacology, 397(Suppl.1), S36-S36. Article P078.

Baier, D., Mendrina, T., Schoenhacker-Alte, B., Pirker, C., Mohr, T., Rusz, M., Regner, B., Schaier, M., Sgarioto, N., Raynal, N. J. M., Nowikovsky, K., Schmidt, W. M., Heffeter, P., Meier-Menches, S. M., Koellensperger, G., Keppler, B. K., & Berger, W. (2023). The Lipid Metabolism as Target and Modulator of BOLD-100 Anticancer Activity: Crosstalk with Histone Acetylation. Advanced science, 10(32), Article 2301939. https://doi.org/10.1002/advs.202301939

Borutzki, Y., Skos, L., Gerner, C., & Meier-Menches, S. M. (2023). Exploring the Potential of Metal-Based Candidate Drugs as Modulators of the Cytoskeleton. ChemBioChem, 24(17), Article e202300178. https://doi.org/10.1002/cbic.202300178

Janker, L., Schuster, D., Bortel, P., Hagn, G., Meier-Menches, S. M., Mohr, T., Mader, J. C., Slany, A., Bileck, A., Brunmair, J., Madl, C., Unger, L., Hennlich, B., Weitmayr, B., Del Favero, G., Pils, D., Pukrop, T., Pfisterer, N., Feichtenschlager, T., & Gerner, C. (2023). Multi-omics empowered deep phenotyping of ulcerative colitis identifies biomarker signatures reporting functional remission states. Journal of Crohn's & colitis, 17(9), 1514-1527. https://doi.org/10.1093/ecco-jcc/jjad052

Zappe, K., Kopic, A., Scheichel, A., Schier, A. K., Schmidt, L. E., Borutzki, Y., Miedl, H., Schreiber, M., Mendrina, T., Pirker, C., Pfeiler, G., Hacker, S., Haslik, W., Pils, D., Bileck, A., Gerner, C., Meier-Menches, S., Heffeter, P., & Cichna-Markl, M. (2023). Aberrant DNA Methylation, Expression, and Occurrence of Transcript Variants of the ABC Transporter ABCA7 in Breast Cancer. Cells, 12(11), Article 1462. https://doi.org/10.3390/cells12111462

Skos, L., Borutzki, Y., Gerner, C., & Meier-Menches, S. M. (2023). Methods to identify protein targets of metal-based drugs. Current opinion in chemical biology, 73, Article 102257. https://doi.org/10.1016/j.cbpa.2022.102257

Hofbauer, T. M., Distelmaier, K., Muqaku, B., Spinka, G., Seidl, V., Arfsten, H. T., Hagn, G., Meier-Menches, S., Bartko, P. E., Pavo, N., Hoke, M., Prausmueller, S., Heitzinger, G., Pils, D., Lang, I. M., Hengstenberg, C., Hülsmann, M. P., Gerner, C., & Goliasch, G. (2023). Metabolomics implicate eicosanoids in severe functional mitral regurgitation. ESC Heart Failure, 10(1), 311-321. https://doi.org/10.1002/ehf2.14160

Kovarik, J. J., Bileck, A., Hagn, G., Meier-Menches, S. M., Frey, T., Kaempf, A., Hollenstein, M., Shoumariyeh, T., Skos, L., Reiter, B., Gerner, M. C., Spannbauer, A., Hasimbegovic, E., Schmidl, D., Garhofer, G., Gyongyosi, M., Schmetterer, K. G., & Gerner, C. (2023). A multi-omics based anti-inflammatory immune signature characterizes long COVID-19 syndrome. Iscience, 26(1), Article 105717. https://doi.org/10.1016/j.isci.2022.105717

Fuchs, V., Cseh, K., Hejl, M., Vician, P., Neuditschko, B., Meier-Menches, S. M., Janker, L., Bileck, A., Gajic, N., Kronberger, J., Schaier, M., Neumayer, S., Koellensperger, G., Gerner, C., Berger, W., Jakupec, M. A., Malarek, M. S., & Keppler, B. K. (2023). Highly Cytotoxic Molybdenocenes with Strong Metabolic Effects Inhibit Tumour Growth in Mice. Chemistry: A European Journal, 29(4), Article e202202648. https://doi.org/10.1002/chem.202202648

Neuditschko, B., King, A. P., Huang, Z., Janker, L., Bileck, A., Borutzki, Y., Marker, S. C., Gerner, C., Wilson, J. J., & Meier-Menches, S. M. (2022). An Anticancer Rhenium Tricarbonyl Targets Fe-S Cluster Biogenesis in Ovarian Cancer Cells. Angewandte Chemie (International Edition), 61(43), Article e202209136. https://doi.org/10.1002/anie.202209136

Brunmair, J., Bileck, A., Schmidl, D., Hagn, G., Meier-Menches, S. M., Hommer, N., Schlatter, A., Gerner, C., & Garhoefer, G. (2022). Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients. The EPMA journal, 13(1), 107-123. https://doi.org/10.1007/s13167-022-00272-7

Prechova, M., Adamova, Z., Schweizer, A. L., Maninova, M., Bauer, A., Kah, D., Meier-Menches, S. M., Wiche, G., Fabry, B., & Gregor, M. (2022). Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets. Journal of Cell Biology, 221(3), Article e202105146. https://doi.org/10.1083/jcb.202105146

Meier-Menches, S. M., Neuditschko, B., Janker, L., Gerner, M. C., Schmetterer, K. G., Reichle, A., & Gerner, C. (2022). A Proteomic Platform Enables to Test for AML Normalization In Vitro. Frontiers in Chemistry, 10, Article 826346. https://doi.org/10.3389/fchem.2022.826346

Baier, D., Schönhacker-Alte, B., Rusz, M., Pirker, C., Mohr, T., Mendrina, T., Kirchhofer, D., Meier-Menches, S. M., Hohenwallner, K., Schaier, M., Rampler, E., Koellensperger, G., Heffeter, P., Keppler, B., & Berger, W. (2022). The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation. Pharmaceutics, 14(2), Article 238. https://doi.org/10.3390/pharmaceutics14020238

Brunmair, J., Gotsmy, M., Niederstaetter, L., Neuditschko, B., Bileck, A., Slany, A., Feuerstein, M. L., Langbauer, C., Janker, L., Zanghellini, J., Meier-Menches, S. M., & Gerner, C. (2021). Finger sweat analysis enables short interval metabolic biomonitoring in humans. Nature Communications, 12(1), Article 5993. https://doi.org/10.1038/s41467-021-26245-4